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Alkoxy substituted imidazo[1,2-a]pyridines having affinity for amyloid
专利权人:
Shigeyuki Tanifuji
发明人:
Shigeyuki Tanifuji,Daisaku Nakamura,Shinya Takasaki,Yuki Okumura
申请号:
US12227487
公开号:
US08303935B2
申请日:
2007.05.15
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides a compound which has affinity with amyloid, shows sufficiently rapid clearance from normal tissues and is suppressed in toxicity such as mutagencity. Provided is a compound represented by the following formula (1) or a salt thereof:wherein A1, A2, A3 and A4 independently represents a carbon or nitrogen R1 is a halogen substituent R2 is a halogen substituent and m is an integer of 0 to 2, provided that at least one of R1 and R2 is a radioactive halogen substituent, at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4 as well as a low-toxic diagnostic agent comprising a compound represented by the preceding formula or a salt thereof.
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