A user moves a handheld inspection device toward a skin region that includes a target skin lesion. A current image of the skin region or part thereof that includes the target skin lesion as currently taken by the handheld inspection device is displayed on a screen, with the target skin lesion marked. When reaching a close distance from the target skin lesion, a close-up inspection is performed. If the target skin lesion is missing in the current image, the close-up inspection process is interrupted, and the user is instructed to move the handheld inspection device to a remote distance from the skin region for restarting the inspection process.
