PROBLEM TO BE SOLVED: To provide a lyophilized formulation containing only a quionolone type synthetic antibacterial compound and a pH regulating agent, and excellent in remelting property.SOLUTION: In this manufacturing method of a non-crystalline lyophilized formulation containing a quionolone type synthetic antibacterial compound as an effective component, a congelation is obtained by cooling an aqueous solution containing a quionolone type synthetic antibacterial compound and a pH regulating agent, once raising its temperature, and cooling it again and lyophilized.COPYRIGHT: (C)2009,JPO&INPIT【課題】キノロン系合成抗菌化合物とpH調節剤のみを含有し、かつ、再溶解性に優れる凍結乾燥製剤の提供。【解決手段】キノロン系合成抗菌化合物およびpH調節剤を含有する水溶液を冷却して凍結体を得、次いで温度を一旦昇温させた後、再度冷却して凍結乾燥することを特徴とする、キノロン系合成抗菌化合物を有効成分とする非晶質凍結乾燥製剤の製造方法。【選択図】なし
