Disclosed are pharmaceutical compositions comprising three antiviral compounds. In particular, the pharmaceutical compositions comprise an effective amount of velpatasvir, an effective amount of sofosbuvir, and an effective amount of voxilaprevir. Also disclosed are methods of use for the pharmaceutical composition.本發明揭示一種醫藥組合物,其包含三種抗病毒化合物。特定言之,該等醫藥組合物包含有效量之維帕他韋(velpatasvir)、有效量之索非布韋(sofosbuvir)及有效量之沃西拉韋(voxilaprevir)。亦揭示該醫藥組合物之使用方法。