Disclosed are pharmaceutical compositions comprising Compound I, having the formula: and an effective amount of sofosbuvir wherein the sofosbuvir is substantially crystalline. Also disclosed are methods of use for the pharmaceutical composition.所揭示者為醫藥組成物,其包含具有下式之化合物I及有效量之索非布偉(sofosbuvir),其中該索非布偉係實質上晶性。所亦揭示者為使用該醫藥組成物之方法。