Conjugated factor VIII molecules

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专利权人:

NOVO NORDISK A/S

发明人:

DEFREES, SHAWN,VANDAHL, BRIAN, BERG, STIDSEN,BOLT, GERT,STENNICKE, HENNING, RALF,THIM, LARS,STEENSTRUP, THOMAS, DOCK

申请号：

DK09714286

公开号：

DK2257311T3

申请日:

2009.02.26

申请国别(地区):

DK

年份:

2014

代理人:

摘要：

The invention concerns B-domain truncated Factor VIII molecules with a modified circulatory half-life, wherein the molecules are covalently conjugated with a hydrophillic polymer via an O-linked oligosaccharide in the truncated B domain, and wherein factor VIII activation results in removal of the covalently conjugated hydrophillic polymer, as well as pharmaceutical compositions comprising said Factor VIII molecules.

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