DEFREES, SHAWN,VANDAHL, BRIAN BERG STIDSEN,BOLT, GERT,STENNICKE, HENNING RALF,THIM, LARS,STEENSTRUP, THOMAS DOCK
申请号：
PL09714286
公开号：
PL2257311T3
申请日:
2009.02.26
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
The invention concerns B-domain truncated Factor VIII molecules with a modified circulatory half-life, wherein the molecules are covalently conjugated with a hydrophillic polymer via an O-linked oligosaccharide in the truncated B domain, and wherein factor VIII activation results in removal of the covalently conjugated hydrophillic polymer, as well as pharmaceutical compositions comprising said Factor VIII molecules.
