J. Thomas August,Gregory George Simon,Tin Wee Tan,Asif Mohammad Khan,Hu Yongli
申请号：
US13520388
公开号：
US20130195904A1
申请日:
2011.01.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
We identified regions of the HIV-1 proteome with high conservation, and low variant incidence. Such highly conserved sequences have direct relevance to the development of new-generation vaccines and diagnostic applications. The immune relevance of these sequences was assessed by their correlation to previously reported human T-cell epitopes and to recently identified human HIV-1 T-cell epitopes (identified using HLA transgenic mice). We identified (a) sequences specific to HIV-1 with no shared identity to other viruses and organisms, and (b) sequences that are specific to primate lentivirus group, with multiclade HIV-1 conservation.
