JAPANESE FOUNDATION FOR CANCER RESEARCH;THE JIKEI UNIVERSITY
发明人:
Masaki ITO,Kiyotaka SHIBA
申请号：
US14901384
公开号：
US20160166665A1
申请日:
2014.06.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A novel vaccine that can induce sufficiently high cell-mediated immunity is disclosed. The vaccine of the present invention contains, as an effective component, a polypeptide comprising a tandem repeat structure in which an MHC class I epitope region derived from an antigen protein and a spacer sequence are linked to each other alternately and repeatedly at least three times, or a recombinant vector which comprises a polynucleotide encoding said polypeptide and is capable of expressing said polypeptide in vivo. The spacer sequence is, for example, a sequence generated as an amino acid sequence inevitably encoded by a single base sequence which is designed such that the MHC class I epitope region derived from the antigen protein, an MHC class II epitope region derived from the antigen protein, and at least one higher-order-structure-stabilizing region are encoded by different reading frames in said single base sequence.
