JING, LAURA JING,HARRIS, CRAIG STEVEN,KARLSSON, ANDERS,SAWEN, ELIN
申请号：
CA3037651
公开号：
CA3037651A1
申请日:
2017.09.20
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to a method of preparing a sterilized injectable hydrogel composition, comprising the steps: a) covalently crosslinking a glycosaminoglycan using a bi- or polyfunctional crosslinking agent to form a covalently crosslinked glycosaminoglycan, b) swelling the covalently crosslinked glycosaminoglycan in a solution comprising a divalent zinc cation to form a hydrogel composition, and c) sterilizing the hydrogel composition by autoclaving to form a sterilized injectable hydrogel composition, and to sterilized injectable hydrogel compositions obtainable by such method.
