Laura Jing JING,Craig Steven HARRIS,Anders KARLSSON,Elin SÄWÉN
申请号：
US16335093
公开号：
US20190351105A1
申请日:
2017.09.20
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A method of preparing a sterilized injectable hydrogel composition, including the steps: a) covalently crosslinking a glycosaminoglycan using a bi- or polyfunctional crosslinking agent to form a covalently crosslinked glycosaminoglycan, b) swelling the covalently crosslinked glycosaminoglycan in a solution including a divalent cation to form a hydrogel composition, and c) sterilizing the hydrogel composition by autoclaving to form a sterilized injectable hydrogel composition, and to sterilized injectable hydrogel compositions obtainable by such method.
