Anti-microbial compositions comprising: an amino acid, a derivative of an amino acid, a salt of an amino acid, a salt of a derivative of an amino acid or mixtures thereof； an anti-microbial component comprising two or more anti-microbial quaternary ammonium compounds, or at least one anti-microbial quaternary ammonium compound and chlorhexidine or a salt thereof； and a polar solvent. The exemplified amino acid derivatives are N-lauroyl-L-arginine ethyl ester monohydrochoride and arginine lactate. The exemplified chlorhexidine salt is chlorhexidine di-gluconate. The exemplified quaternary ammonium compounds are didecyldimethyl ammonium chloride (DDAC) and benzalkonium chloride (BAC). In particular, the invention relates to antimicrobial compositions that can be used on skin. Also claimed are a hand sanitizer, a wound care product and an anti-microbial wipe comprising the antimicrobial composition.
