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COMPOSITIONS PHARMACEUTIQUES ET PROCEDES DE FABRICATION DE MASSES SOLIDES COMPRENANT DES POLYPEPTIDES ET/OU DES PROTEINES
专利权人:
INCUBE LABS; LLC
发明人:
IMRAN, MIR,MORALES, MERCEDES,KORUPOLU, RADHIKA,TO, ELAINE,HARRIS, JOEL,HASHIM, MIR
申请号:
CA2983337
公开号:
CA2983337A1
申请日:
2016.05.02
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-a-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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