An oil based composition for external use on skin for enhancing percutaneous absorption of a water-soluble agent contains 50% by mass to 95% by mass of an oil constituent, which contains 10% by mass to 100% by mass of a solid or semisolid oil constituent, and 5% by mass to 50% by mass of particles. The composition has occlusivity of at least 50% and is adapted for use such that, after a preparation for external use on skin, which preparation contains a water-soluble agent, has been applied onto skin, the composition may be applied onto the preparation for external use on skin, which preparation has been applied onto the skin. A method of enhancing percutaneous absorption of a water-soluble agent utilizes the composition.本發明係關於一種水溶性藥劑之經皮吸收促進用油性皮膚外用組合物，其特徵為含有50~95質量%之含10~100質量%之固形或半固形油分的油分及5~50質量%之粉末，且具有50%以上之閉塞性，在皮膚上應用含水溶性藥劑之皮膚外用劑後再應用於其上；以及一種使用有該組合物之水溶性藥劑的經皮吸收促進方法。
