AGARD, Nicholas, J.,MILLER, Mathew, G.,ZHANG, Xiyun,HUISMAN, Gjalt, W.
申请号：
EP15874075
公开号：
EP3237621A4
申请日:
2015.12.02
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH <；4.5) and basic (pH >；7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
