Nicholas J. Agard,Mathew G. Miller,Xiyun Zhang,Gjalt W. Huisman
申请号：
US15529383
公开号：
US20170360900A1
申请日:
2015.12.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH <；4.5) and basic (pH >；7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
