The present invention relates to an antibody or binding fragment thereof that binds to a fraction of T cell receptor variable alpha (TCR Vα) chains comprising at least two different TCR Vα chains but less than all TCR Vα chains or that binds to a fraction of T cell receptor variable beta (TCR Vβ) chains comprising at least two different TCR Vβ chains but less than all TCR Vβ chains.