The present invention relates to peptides comprising analogs of VDAC1-derived peptides with improved pharmacokinetic properties compared to the natural parent peptide, which peptides impair cellular energy production, apoptosis and cell death, particularly cancer cells. It is effective in alleviating symptoms associated with induction of cell death, removal of cancer stem cells, and accumulation of fat in hepatocytes, particularly nonalcoholic fatty liver disease (NAFLD) and associated symptoms. [Selection figure] None本発明は、天然の親ペプチドと比較して薬物動態特性が改善されたＶＤＡＣ１由来ペプチドの類似体を含むペプチドに関し、これらのペプチドは、細胞エネルギー産生の障害、アポトーシスと細胞死、特に癌細胞の細胞死の誘導、癌幹細胞の除去、および肝細胞内の脂肪の蓄積に伴う症状、特に非アルコール性脂肪性肝疾患（ＮＡＦＬＤ）とそれに伴う症状の軽減に効果がある。【選択図】なし
