JAIN, NEERA,YING, WEIWEN,CHIMMANAMADA, DINESH U.,ZHANG, JUNYI,KALE, AMIT
申请号：
CA3067572
公开号：
CA3067572A1
申请日:
2018.06.19
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.
