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AGENTS THERAPEUTIQUES CIBLES
专利权人:
SYNTA PHARMACEUTICALS CORP.
发明人:
CHIMMANAMADA, DINESH U.,YING, WEIWEN
申请号:
CA2870357
公开号:
CA2870357A1
申请日:
2013.04.16
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.
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