A method displays an ultrasound image of subject tissue that defines a region of interest, the image acquired in a first measurement mode. In response to an operator instruction, the method switches to a second measurement mode, analyzes the subject tissue within the region of interest for compatibility with the second measurement mode, and highlights one or more areas of the subject tissue for removal from the region of interest, displaying a revised region of interest according to the mode compatibility analysis. One or more signals for the second measurement mode are directed to the revised region of interest and measurement results displayed.