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Fe (iii) complex compounds for the treatment and prophylaxis of iron deficiency symptoms and iron deficiency anemias
专利权人:
Vifor (International) AG
发明人:
BARK, Thomas,BUHR, Wilm,BURCKHARDT, Susanna,BURGERT, Michael,CANCLINI, Camillo,DÜRRENBERGER, Franz,FUNK, Felix,GEISSER, Peter,KALOGERAKIS, Aris,MAYER, Simona,PHILIPP, Erik,REIM, Stefan,SIEBER, Diana,S
申请号:
ES11710182
公开号:
ES2660202T3
申请日:
2011.03.22
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Iron complex compounds (III), which contain at least one ligand of the formula (I): ** Formula ** characterized by the fact that the arrows respectively represent a coordinated bond to one or different iron atoms , R1 is selected from the group consisting of optionally substituted alkyl, and optionally substituted alkoxycarbonyl R2 is selected from the group consisting of hydrogen, optionally substituted alkyl, halogen or cyano, or R1 and R2, together with the carbon atoms at which are linked, form a ring of 5 or 6 optionally substituted elements, which may optionally contain one or more heteroatoms, R3 and R4 are the same or different and are respectively selected from the group consisting of hydrogen, optionally substituted amino and alkyl optionally substituted, or R3 and R4, together with the nitrogen atom to which they are linked, form a ring of 3 to 6 elements optionally substituted, which may optionally contain one or more additional heteroatoms, or R2 and R3 together form a ring of 5 or 6 optionally substituted, saturated or unsaturated elements, while forming a ligand of the formula (Ia): ** Formula ** characterized in that R1 and R4 are as defined above lines, or R2 and R3 together form an optionally substituted, saturated or unsaturated ring of 5 or 6 elements, and R1 and R2 together form an optionally substituted, saturated 5 or 6 element ring together or unsaturated, while forming a ligand of the formula (Ib): ** Formula ** characterized in that R4 is conforming is defined above, and characterized in that when R1 is phenyl, neither R3 nor R4 are phenyl, or the salts of the same pharmaceutically acceptable.Compuestos del complejo de hierro(III), que contienen por lo menos un ligando de la fórmula (I):**Fórmula** que se caracteriza por el hecho de que las flechas representan respectivamente un enlace coordinado a uno o diferentes átomos de hierro, R1 se selecciona del grupo que está compuesto por alquilo opcionalmente sustituido, y alcoxicarbonilo opciona
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