Malay PATRA,Gilles GASSER,Thomas L. MINDT,Andreas BAUMAN,PATRA, Malay,GASSER, Gilles,MINDT, Thomas, L.,BAUMAN, Andreas
申请号：
US15127025
公开号：
US20170106106A1
申请日:
2015.03.18
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention relates to octadentate ligands of a general formula R1-D-X-D-X-D-X-D-E-R2, wherein D is C(O)N(OH) or N(OH)C(O), pyrimidinone or pyridinone, each X independently of any other X is a saturated or partially unsaturated, substituted or unsubstituted linker comprising 8-11 atoms selected from any of N, C, O； R1 is alkyl, cycloalkyl, arene, or heteroarene, E is a saturated or partially unsaturated, substituted or unsubstituted chain comprising 1-50 atoms and R2 is a moiety capable of selectively binding to a biomolecule, or a nanoparticle. The invention further relates to complexes of the ligand, particularly radionuclides and their use in radioimmunotherapy and imaging.
