SCREENING FOR AGENTS THAT TARGET THE ACTIN CYTOSKELETON USING C. ELEGANS EXPOSED TO HEAT SHOCK

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专利权人:

The State University of New Jersey;Rutgers

发明人:

Federico Sesti,Rahul Patel

申请号：

US16468239

公开号：

US20200080991A1

申请日:

2018.01.19

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Provided herein are screening methods that utilize transgenic nematodes exposed to heat shock conditions, such as agents that increase stability of F-actin. The transgenic nematodes used can be in a wild-type background, functionally deleted for OSG-1, or express human ARHGEF10 in an OSG-1 background. Such transgenic nematodes also express a fluorescent protein, such as GFP. Such methods are in some examples high throughput and automated. Also provided are recombinant nematodes and kits that can be used with such methods.

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