Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof

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专利权人:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人:

HECKEL ARMIN,FRATTINI SARA,HAMPRECHT DIETER,KLEY JOERG

申请号：

NZ62246912

公开号：

NZ622469A

申请日:

2012.10.29

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Provided are diaminopyrazine derivative compounds of the general formula (I), wherein the variables are as defined in the specification. Examples of the compounds include 4-[N&rsquo-(3,5-Diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxylic acid tert-butyl ester and 4-[N&rsquo-(3,5-Diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxamidine . The compounds are inhibitors of epithelial sodium channels (ENaC). The compounds may be useful in the treatment of respiratory diseases such as cystic fibrosis.

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