The present invention relates to compounds defined by formula I wherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this protein.本發明係關於式I定義之化合物,其中變數R1至R8為如說明書中所定義,其具有有用的藥理活性。特定言之,該等化合物為膽固醇酯轉移蛋白(CETP)之抑制劑,因此適用於治療及預防可由抑制該蛋白質而影響之疾病。