SOLVATE DE DIMÉTHYLSULFOXYDE N-{3-[3-CYCLOPROPYL-5-(2-FLUORO-4-IODOPHÉNYLAMINO)-6,8-DIMÉTHYL-2,4,7-TRIOXO-3,4,6,7-TÉTRAHYDRO-2N-PYRIDO[4,3-D]PYRIMIDIN-1-YL]-PHÉNYL}- CYCLOPROPANECARBOXAMIDE UTILISÉ EN TANT QUE INHIBITEUR DE MEK1/2

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专利权人:

R-Pharm Joint Stock Company (R-Pharm, JSC);Repik, Alexey Evgenievich

发明人:

REPIK, Alexey Evgenievich,IVACHTCHENKO, Alexandre Vasilievich,IGNATIEV, Vasily Gennadievich,CHAFEEV, Mikhail Airatovich

申请号：

EP16918763

公开号：

EP3524601A4

申请日:

2016.12.12

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The aim of the present invention is to create novel MEK1, MEK2 and MEK1/2 inhibitors which have lower toxicity in long-term dosage. This aim is achieved by the novel compound N- {3-[3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]-phenyl}-cyclopropanecarboxamide dimethyl sulfoxide solvate of formula 1

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