SOLVATE DE DIMETHYLSULFOXYDE N-{3-[3-CYCLOPROPYL-5-(2-FLUORO-4-IODOPHENYLAMINO)-6,8-DIMETHYL-2,4,7-TRIOXO-3,4,6,7-TETRAHYDRO-2N-PYRIDO[4,3-D]PYRIMIDIN-1-YL]-PHENYL}- CYCLOPROPANECARBOXAMIDE UTILISE EN TANT QUE INHIBITEUR DE MEK1/2

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专利权人:

REPIK, ALEXEY EVGENIEVICH;R-PHARM JOINT STOCK COMPANY (R-PHARM; JSC);R-PHARM JOINT STOCK COMPANY (R-PHARM, JSC)

发明人:

REPIK, ALEXEY EVGENIEVICH,IVACHTCHENKO, ALEXANDRE VASILIEVICH,IGNATIEV, VASILY GENNADIEVICH,CHAFEEV, MIKHAIL AIRATOVICH

申请号：

CA3039524

公开号：

CA3039524A1

申请日:

2016.12.12

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The aim of the present invention is to create novel MEK1, MEK2 and MEK1/2 inhibitors which have lower toxicity in long-term dosage. This aim is achieved by the novel compound N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]-phenyl}-cyclopropanecarboxamide dimethyl sulphoxide solvate of formula 1.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/