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Hydroxyphenyl pyrrole compounds containing an hydroxamic acid as hdac inhibitors and medicinal applications thereof
专利权人:
发明人:
申请号:
EP11382101.1
公开号:
EP2508510A1
申请日:
2011.04.06
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention refers to compounds derived from hydroxyphenyl 1H-pyrrole rings, which have the following formula (I):as well as to the procedure for their preparation, pharmaceutical compositions comprising the same and the use thereof for the treatment and/or prevention of a condition mediated by histone deacetylase such as cancer, hematological malignancies, autoimmune diseases, inflammatory diseases, diseases of the central nervous system (CNS) such as neurodegenerative diseases and psychiatric disorders, cardiovascular diseases, endocrine and metabolic disorders, by inhibiting histone deacetylases and the therapeutic use of biological processes related to the mentioned inhibition.
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