COMPOSITIONS ET MÉTHODES DESTINÉES À L'INDUCTION DE LA TOLÉRANCE IMMUNE DANS LE CADRE DE THÉRAPIES DE REMPLACEMENT DE FACTEUR VIII CHEZ LES PATIENTS SOUFFRANT D'HÉMOPHILIE A
INC.;HAPLOMICS, INC.;DEPARTMENT OF VETERANS AFFAIRS;HAPLOMICS;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
HOWARD, TOMMY, E.,LA TERZA, VINCENT
申请号：
EP14765535
公开号：
EP2968499A4
申请日:
2014.03.17
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
This disclosure relates to tolerance inducing peptide (TIP) derived from the amino acid reference locus (AARL) within a FVIII replacement product (FVIIIrp) based on the differences between the expression product of a subject's F8 gene (sFVIII) and the FVIIIrp to provide tolerance induction before, during, and/or after a FVIII replacement therapy in a subject suffering from Hemophila A. Methods of deriving, making, and using the TIP are also disclosed. In some embodiments, the TIP is associated with a nanoparticle, e.g., PLGA or PLGA-PEMA nanoparticle.
