Marc Stefan Robillard,George Thomas Robillard,Armagan Kocer
申请号：
US12993130
公开号：
US08623325B2
申请日:
2009.05.26
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention describes the modification of polypeptides, more particularly channel proteins with a thiol reactive agent so as to introduce an azide group. The present invention further describes vesicles comprising channel proteins modified according to the invention, which upon reaction with a phosphine open up thereby releasing the content of the vesicles. The reagents, polypeptides and vesicles described in the present invention have in vivo and in vitro applications in both drug delivery and imaging.
