600382 Discloses a bG-CSF polypeptide comprising a non-naturally encoded amino acid substituted at position 133 of SEQ ID NO: 1 or the corresponding amino acid in SEQ ID NO: 2, where the non-naturally encoded amino acid is reactive toward a linker, polymer or biologically active molecule. Where the non-naturally encoded amino acid comprises carbonyl group, an aminooxy group, a hydrazine group, a hydrazide group, a semicarbazine group, an azide group or an alkyne group but where the amino acid is no para-acetylphenylalanine.
