The present invention relates to the field of oncology and providescompositions and methods for treating specificcancers, including non small cell lung cancer, breast cancer, thyroid cancer,pancreatic cancer, colon cancer, melanoma, hepatomaand adenocarcinoma. Particularly, compositions and methods involvingadministration, either simultaneously or sequentially, ofpharmaceutical combinations comprising (S)-N- (3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide with other compounds, to patients suffering fromcancer are described.