MOLÉCULES DE FACTEUR VIII CONJUGUÉES

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专利权人:

NOVO NORDISK A/S

发明人:

申请号：

EP09714286.3

公开号：

EP2257311B1

申请日:

2009.02.26

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The invention concerns B-domain truncated Factor VIII molecules with a modified circulatory half-life, wherein the molecules are covalently conjugated with a hydrophillic polymer via an O-linked oligosaccharide in the truncated B domain, and wherein factor VIII activation results in removal of the covalently conjugated hydrophillic polymer, as well as pharmaceutical compositions comprising said Factor VIII molecules.

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