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patch composition including natural component and patch manufacturing method using the same
专利权人:
MEDICELL CO., LTD.;KIM, JEOUNG HYOUN;주식회사 메디셀;김정현
发明人:
김정현,문정민
申请号:
KR1020200047577
公开号:
KR1021434010000B1
申请日:
2020.04.20
申请国别(地区):
KR
年份:
2020
代理人:
摘要:
The present invention is a liposomal herbal ingredient for treating or alleviating joint pain by allowing it to penetrate into the skin by a transdermal drug delivery component while eluting a herbal drug extract having an effect of helping to treat or relieve joint pain. It relates to a transdermal drug delivery patch composition and a patch manufacturing method using the composition. The transdermal drug delivery patch composition for the treatment of joint pain of the present invention comprises a herbal extract consisting of peppermint leaves, Ecklonia cava, cinnamon sticks and gasiogapi, a transdermal drug delivery component, and a hydrogel that changes from a gel state to a sol state in response to skin temperature. The composition is mixed, but the herbal medicine extract is composed of a mixture of peppermint leaves, Ecklonia cava, cinnamon sticks and gasiogapi at a weight ratio of 1 to 2: 1 to 2: 1: 1 to 2, respectively, and the herbal extracts are phospholipids and 0.2 to 1 : In the state of being mixed at a weight ratio of 1, sonication is performed for 3 to 5 seconds at 1 to 3 seconds intervals for 2 to 30 minutes, so that the herbal medicine extract component is divided into nanoparticles, surrounded by phospholipids, and is liposomed, and herbal extracts 5 to 15 Wt% and 45 to 55 wt% of polyacrylic acid as a transdermal drug delivery component, 0.4 to 2 wt% of agar as a hydrogel material, 0.01 to 0.5 wt% of sodium hydroxide, 5 to 15 wt% of glycerin, 3 to of methylpropanediol 7% by weight, sodium polyacrylate 0.2-1% by weight, aluminum glycinate 0.05-0.5% by weight, and the rest are mixed with purified water.본 발명은 관절 통증의 치료 또는 완화시키는데 도움을 주는 효능을 갖는 생약추출물을 용출시키면서 경피약물전달성분에 의해 피부로 침투되게 함으로써 관절통증을 치료 또는 완화시켜 주도록 한 관절통증치료용 리포좀화된 생약성분 경피약물전달 패치 조성물 및 이 조성물을 이용한 패치 제조방법에 관한 것이다.본 발명의 관절통증치료용 리포좀화된 생약성분 경피약물전달 패치 조성물은 박하잎과 감태와 천궁 및 가시오가피로 이루어진 생약추출물과 경피약물전달성분 및 피부온도에 감응하여 겔상태에서 졸상태로 변하는 하이드로겔 조성물을 혼합하되, 상기 생약추출물은 박하잎과 감태와 천궁 및 가시오가피가 각각 1~2 : 1~2 : 1 : 1~2의 중량비율
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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