The present invention relates to a pharmaceutical composition containing a crude extract of the hybrid H-387-07-GISeM, which is a product of which is the product of crossbred of varieties: Sechium edule var. virens levis with Sechium edule var. amarus silvestrys and the crossbred of its result with Sechium edule var. nigrum spinosum, which has therapeutic effectiveness as antineoplastic agent said composition has an improved effect compared with its parents and also its administration has no side effects.