PURPOSE: A composition for ischemic brain disease treatment is provided to reduce the size of cerebral edema and cerebral infarction domain, to reduce the level of lipid peroxidation and encephalopathy, and to show a brain protecting activation, thereby realizing a possibility of being developed as a therapeutic agent for ischemic brain disease. CONSTITUTION: A composition for preventing or curing ischemic brain disease comprises Rosa hybrid extract as an active ingredient. The rosa hybrid extract is a solvent extract extracted by using more than one solvent selected from a group comprising water, 1-4 carbon numbers of hydrated or non-hydrated lower alcohol, acetone, ethyl acetate, butylacetate, chloroform, hexane, diethylether, and 1,3- butylene glycol. The ischemic brain disease is stroke, cerebral infarction, cerebral ischemia, hypoxia brain damage, or traumatic brain injury. A food composition for improving ischemic brain disease comprises the rosa hybrid extract as an active ingredient.본 발명은 장미꽃 추출물을 유효성분으로 포함하는 허혈성 뇌질환의 예방, 치료 또는 개선용 조성물에 관한 것이다. 본 발명의 활성성분인 장미꽃 추출물은 중뇌동맥폐색 및 재관류에 의해 유도된 허혈성 뇌손상에서 뇌경색 영역 및 뇌부종의 크기를 감소시키고, 지질과산화 및 뇌염증 수준을 낮추며, 뇌손상 및 행동장애를 크게 개선시키는 뇌보호 활성을 나타낸다. 따라서, 본 발명의 조성물은 허혈성 뇌질환의 치료제로 개발될 수 있다.
