Individual anti immunoglobulin variable Domain which encodes tgfbetarii； Nucleic Acid； vector； host Cell； production method； Pharmaceutical Composition and its use in treating a disease associated with the TGFbeta Signaling.
FORD SUSANNAH KAREN,BEATON, ANDREW,DIMECH CAROLINE,ETTL PETER FRANZ,MCADAM RUTH
申请号：
CL2013001975
公开号：
CL2013001975A1
申请日:
2013.07.05
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis； liver fibrosis, including cirrhosis and chronic hepatitis； rheumatoid arthritis； ocular disorders； fibrosis of the skin, including keloid of skin； Dupuytren's Contracture； kidney fibrosis such as nephritis and nephrosclerosis； wound healing； scarring reduction； and a vascular condition, such as restenosis.DOMINIO VARIABLE INDIVIDUAL DE INMUNOGLOBULINA ANTI-TGFbetaRII； ACIDO NUCLEICO QUE LO CODIFICA； VECTOR； CELULA HUESPED； METODO DE PRODUCCION； COMPOSICION FARMACEUTICA； Y SU USO PARA TRATAR UNA ENFERMEDAD ASOCIADA CON LA SEÑALIZACION DE TGFbeta.
