Individual anti immunoglobulin variable Domain which encodes tgfbetarii; Nucleic Acid; vector; host Cell; production method; Pharmaceutical Composition and its use in treating a disease associated with the TGFbeta Signaling.
FORD SUSANNAH KAREN,BEATON, ANDREW,DIMECH CAROLINE,ETTL PETER FRANZ,MCADAM RUTH
申请号:
CL2013001975
公开号:
CL2013001975A1
申请日:
2013.07.05
申请国别(地区):
CL
年份:
2014
代理人:
摘要:
The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis.DOMINIO VARIABLE INDIVIDUAL DE INMUNOGLOBULINA ANTI-TGFbetaRII; ACIDO NUCLEICO QUE LO CODIFICA; VECTOR; CELULA HUESPED; METODO DE PRODUCCION; COMPOSICION FARMACEUTICA; Y SU USO PARA TRATAR UNA ENFERMEDAD ASOCIADA CON LA SEÑALIZACION DE TGFbeta.