Chari, Ravi V. J.,Singh, Rajeeva,Wilhelm, Sharon D.,Kovtun, Yelena
申请号：
AU2009243009
公开号：
AU2009243009B2
申请日:
2009.04.30
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Linkers for binding drugs to cell binding agents are modified to hydrophilic linkers by incorporating a polyethylene glycol spacer. The potency or the efficacy of the cell-binding agent-drug conjugates is surprisingly enhanced several folds in a variety of cancer cell types, including those expressing a low number of antigens on the cell surface or cancer cells that are resistant to treatment.
