Antonlo Rodriguez Hergueta;Francisco Javier Ramos Lima;Rosa Maria Alvarez Escobar;Ana Isabel Higueras Hernandez;Joaquin Pastor Fernández;Sonia Martínez Gonzalez
发明人:
Joaquin Pastor Fernández,Sonia Martínez Gonzalez,Antonlo Rodriguez Hergueta,Francisco Javier Ramos Lima,Rosa Maria Alvarez Escobar,Ana Isabel Higueras Hernandez
申请号：
US13697499
公开号：
US20130131057A1
申请日:
2011.05.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
There is provided compounds of formula (I), wherein A1, A4, A4a, A5, B1, B1a, B2, B2a, B3, B3a, B4, B4a and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
