Lynn MacDonald,Min Gao,Marc R. Morra,Nicole M. Alessandri-Haber,Michael L. LaCroix-Fralish
申请号：
US13753836
公开号：
US09150648B2
申请日:
2013.01.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders.
