Lynn MacDonald,Min Gao,Marc R. Morra,Nicole M. Alessandri-Haber,Michael L. LaCroix-Fralish
申请号：
US14068173
公开号：
US09371383B2
申请日:
2013.10.31
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. According to certain embodiments, the antibodies of the invention are selective for ASIC1 and do not bind other acid-sensing ion channels in the absence of ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders.
