Guohua Chen,Paul R. Houston,Lothar Walter Kleiner,John J. Spaltro
申请号：
US10295814
公开号：
US08252303B2
申请日:
2002.11.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having a miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patients body surface by injection.
