The present invention discloses a mouse-human chimeric antibody that preferentially recognizes the MUC1 glycopeptide epitope RPAPGS (GalNAc) TAPPAHG on the surface of cancer cells, and a coding sequence in which the monoclonal antibody has a light chain and a heavy chain. In addition, the present invention provides humanized light and heavy chains, and coding sequences. The results of pair expression indicate that the humanized antibody also recognizes the MUC1 glycopeptide epitope RPAPGS (GalNAc) TAPAPHG on the surface of cancer cells and shows the same specificity as the parent antibody.本発明は、癌細胞の表面上のMUC1糖ペプチドエピトープRPAPGS（GalNAc）TAPPAHGを優先的に認識するマウス-ヒトキメラ抗体、ならびにモノクローナル抗体が軽鎖および重鎖を有するコード配列を開示する。さらに、本発明は、ヒト化の軽鎖および重鎖、ならびにコード配列を提供する。ペア発現の結果は、ヒト化抗体も癌細胞の表面上のMUC1糖ペプチドエピトープRPAPGS（GalNAc）TAPAPHGを認識し、そして親抗体と同じ特異性を示すことを示す。
