NANOCRUISE PHARMACEUTICAL;Board of Regents of The University of Texas System
发明人:
Dapeng ZHOU,Patrick HWU
申请号：
US16478833
公开号：
US20200115466A1
申请日:
2017.01.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention discloses a mouse-human chimeric antibody preferably recognizes the MUC1 glycopeptide epitope RPAPGS(GalNAc)TAPPAHG on the surface of cancer cells, and the encoding sequences, wherein the monoclonal antibody having a light chain and a heavy chain. Moreover, the present invention provides humanized light and heavy chains, and the encoding sequences. The results of paired expression show that humanized antibodies also recognize the MUC1 glycopeptide epitope RPAPGS(GalNAc)TAPPAHG on the surface of cancer cells, and show the same specificity as the parental antibody.
