"immunogenic peptide composition for prevention and treatment of alzheimer's disease". The present invention relates to a composition comprising a peptide immunogen useful for the prevention and treatment of alzheimer's disease. more particularly, the peptide immunogen comprises a major functional / regulatory site, an n-terminal fragment of the <；225>； (a <；225>；) amyloid peptide bound to a multi-motif helper (th) epitope of binding to mhx class ii. the peptide immunogen prompts a site-directed immune response against the peptide's major functional / regulatory site at <；225>； and generates antibodies, which are highly reactive by crossing the soluble <；225>； ~ 1-42 ~ peptide and formed amyloid plaques. in the brain of patients with alzheimer's disease. antibodies requested being cross-reactive to the soluble <；225>； ~ 1-42 ~ peptide, promote fibrillar disaggregation and inhibit fibrillar aggregation leading to immunoneutralization of the Î ± -soluble derived toxins and being cross reactive to amyloid plaques , accelerate the output of these brain plaques. therefore, the composition of the invention comprising the peptide immunogen is useful in the prevention and treatment of alzheimer's disease."composição de peptídeo imunogênico para prevenção e tratamento da doença de alzheimer". a presente invenção refere-se a uma composição compreendendo um imunógeno peptídico útil para prevenção e tratamento da doença de alzheimer. mais particularmente, o imunógeno peptídico compreende um sítio funcional/regulatório principal, um fragmento n-terminal do peptídeo amilóide <；225>； (a<；225>；) ligado a um epítopo de célula t auxiliar (th) com motivos múltiplos de ligação a mhx classe ii. o imunógeno peptídico solicita uma resposta imune direcionada ao sítio contra o sítio funcional/regulatório principal do peptídeo a<；225>； e gera anticorpos, que são altamente reativos por cruzamento ao peptídeo a<；225>；~ 1-42~ solúvel e a placas amilóides form
