Methods and materials for assessing responsiveness to PARP inhibitors and platinating agents

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专利权人:

发明人:

Scott H. Kaufmann,Anand G. Patel

申请号：

US13679756

公开号：

US08729048B2

申请日:

2012.11.16

申请国别(地区):

US

年份:

2014

代理人:

摘要：

This document provides methods and materials involved in assessing responsiveness to PARP inhibitors and platinating agents. For example, methods and materials for using levels of non-homologous end-joining pathway members (e.g., artemis mRNA or polypeptide levels, Ku80 mRNA or polypeptide levels, or DNA-PKcs mRNA or polypeptide levels) to determine if cancer cells that are homologous recombination-deficient are likely to be susceptible or resistant to PARP inhibitors and platinating agents are provided.

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中国工程科技知识中心

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http://www.ckcest.cn/home/