A MONOCLONAL ANTIBODY FRAMEWORK BINDING INTERFACE FOR MEDITOPES, MEDITOPE DELIVERY SYSTEMS AND METHODS FOR THEIR USE

• 收藏
• 分享

专利权人:

ZER, CINDY;WILLIAMS, JOHN C.;CITY OF HOPE;MA, YUELONG; JOHN C.;HORNE, DAVID, A.;BZYMEK, KRZYSZTOF;DONALDSON, JOSHUA, MICHAEL;AVERY, KENDRA, NICOLE;WILLIAMS

发明人:

WILLIAMS, JOHN C.,DONALDSON, JOSHUA, MICHAEL,HORNE, DAVID, A.,MA, YUELONG,ZER, CINDY,BZYMEK, KRZYSZTOF,AVERY, KENDRA, NICOLE

申请号：

SG2013026174

公开号：

SG189313A1

申请日:

2011.10.10

申请国别(地区):

SG

年份:

2013

代理人:

摘要：

An antibody framework binding interface for the cyclic meditopes C-QFDLSTRRLK-C (cQFD； SEQ ID NO:1) and C-QYNLSSRALK-C (cQYN； SEQ ID NO:2) and methods for their use are provided herein. In one embodiment, a binding interface is formed by a framework region, and not a complementarity determining region (CDR), of an antibody or functional fragment thereof. In another embodiment, a therapeutic human or humanized antibody has one or more human framework residues replaced with one or more corresponding murine residues such that a meditope having the sequence cQFD or cQYN stably binds the one or more human framework residues.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/