The present invention provides a device that can move inside a biological conduit such as an intestinal tract for sampling the content therein, and a process thereof. The device includes a flexible tube, a proximal handling system connected to a proximal end of the tube； and one or more sampling channels within the tube. Discrete hairs and/or continuous belt in the sampling channels are designed to collect the content within the conduit. The hairs and belt loaded with the sample may be used to establish a chemical, biochemical and microbiological spectrum along the length of the intestinal tract.
