Mark E. GURNEY;Munagala RAO;Jasbir SINGH;Alex BURGIN;Alexander KISELYOV
发明人:
Jasbir SINGH,Mark E. GURNEY,Alex BURGIN,Alexander KISELYOV,Munagala RAO
申请号：
US13454487
公开号：
US20120207729A1
申请日:
2012.04.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I:in which A and B are carbocycles or heterocycles. A particular embodiment is
